Cancerfighter’s Weblog

Alternative cancer therapies and ideas

PARP inhibitors and cancer

Posted by Jonathan Chamberlain on November 4, 2009


The Big Book: Cancer: The Complete Recovery Guide

The Small Book: Cancer Recovery Guide: 15 Alternative and Complementary Strategies for Restoring Health  –  For more information go to www.fightingcancer.com

“This book tells me everything. Why didn’t my doctor tell me this.”

 

PARP INHIBITORS

“Poly(ADP-ribose) polymerase (PARP) is a key enzyme involved in the repair of single-strand breaks in DNA via the Base Excision Repair pathway. Breakthrough scientists found that cells deficient for either BRCA1 or BRCA2 are particularly sensitive to the inhibition of PARP enzymatic activity; this results in chromosomal instability, cell cycle arrest and subsequent apoptosis.” – http://www.breakthroughresearch.org.uk/clinical_trials_clinical_researchers/clinical_trials/parp_inhibitor_trial/index.html

What that means is PARP is an enzyme that helps cancer cells repair themselves. Anything that inhibits the enzyme will prevent the cell from repairing itself. So, if at the same time you are taking herbs or drugs that attack cancer cells, then simultaneously also taking a PARP inhibitor should improve the effectiveness of the treatment. There are a number of new drug PARP inhibitors coming onto the market and this would be something to discuss with your oncologist.

Herbal PARP inhibitors are Honokiol herb (also a ‘happy pill’ and a possible Viagra substitute) and the Chinese herb Scutellaria barbata

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

 
%d bloggers like this: