brain cancer treatment?
Posted by Jonathan Chamberlain on June 10, 2008
From Steve Martin’s website at www.grouppekurosawa.com:
I have written about this many times. Chemo drugs and radiation induce massive inflammation in the brain. The swelling, edema, must be controlled or the patient can die. So it is standard medical practice to treat the patient with the steroid dexamethasone. This controls the inflammation. Unfortunately, dexamethasone prevents the cancer cells from dying of programmed cell death.
A few weeks ago I wrote an essay on the inhibition of glycolysis by methyl jasmonate and lithium.
We have a member in Europe whose brother has melanoma metastasized to his brain. He has purchased methyl jasmonate which will be introduced into the brain via the nose. We are going to add lithium orotate to this mix.
Lithium orotate is a neuroprotectant. It induces autophagy, but not cell death in the absence of oxidative stress. Methyl jasmonate, by virtue of its ability to reduce ATP levels in cells, will definitely induce oxidative stress.
Further, both compounds detach hexokinase from the mitochondria, thereby blocking aerobic glycolysis and promoting, eventually, programmed cell death.
Methyl jasmonate is toxic to neuroblastoma cancer cells but not normal neurons.
One of the nice properties of methyl jasmonate is its efficacy in chemo drug resistant and mutant p53 cancer cells.
Since the nose is a direct conduit to brain, the combination of low doses of methyl jasmonate and lithium administered nasally could be the perfect treatment for brain cancer and localized metastatic cells.
My beloved Uncle Buddy died of brain cancer so this disease has taken on a personal importance for me.